TargetMol

GLP-1R Antagonist 1

Product Code:
 
TAR-T15387
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15387-1mg1mg£101.00
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TAR-T15387-5mg5mg£142.00
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TAR-T15387-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T15387-10mg10mg£189.00
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TAR-T15387-25mg25mg£301.00
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TAR-T15387-50mg50mg£436.00
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Further Information

Bioactivity:
GLP-1R Antagonist 1 is an orally active, CNS penetrant and non-competitive glucagon-like peptide 1 receptor (GLP-1R) antagonist (IC50: 650 nM).
CAS:
488097-06-9
Formula:
C16H11ClF6N4O2
Molecular Weight:
440.73
Pathway:
GPCR/G Protein
Purity:
0.98
SMILES:
Cn1c2NC(=NC(c2c(=O)n(C)c1=O)(C(F)(F)F)C(F)(F)F)c1ccc(Cl)cc1
Target:
Glucagon Receptor

References

Kellie D. Nance, et al. Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core. J. Med. Chem. 19 Jan 2017.