TargetMol

LLY-283

Product Code:
 
TAR-T15767
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T15767-10mg10mgEnquire
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TAR-T15767-50mg50mgEnquire
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TAR-T15767-1mg1mg£98.00
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TAR-T15767-5mg5mg£134.00
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TAR-T15767-1mL1 mL * 10 mM (in DMSO)£141.00
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Further Information

Bioactivity:
LLY-283 is an effective and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) (IC50: 22 nM and a Kd: 6 nM for PRMT5:MEP50 complex). It also shows antitumor activity.
CAS:
2040291-27-6
Formula:
C17H18N4O4
Molecular Weight:
342.355
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
[H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12)[C@H](O)c1ccccc1
Target:
Histone Methyltransferase

References

Zahid Q. Bonday, et al. LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Med. Chem. Lett., 2018, 9 (7), pp 612-617.