TargetMol

Laduviglusib trihydrochloride

Product Code:
 
TAR-T22657
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22657-1mg1mg£99.00
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TAR-T22657-2mg2mg£112.00
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TAR-T22657-5mg5mg£139.00
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TAR-T22657-1mL1 mL * 10 mM (in DMSO)£157.00
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TAR-T22657-10mg10mg£181.00
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TAR-T22657-25mg25mg£298.00
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TAR-T22657-50mg50mg£501.00
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TAR-T22657-100mg100mg£647.00
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TAR-T22657-500mg500mg£1,267.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
glycogen synthase kinase 3 (GSK-3) inhibitor
CAS:
1782235-14-6
Formula:
C22H21Cl5N8
Molecular Weight:
574.72
Pathway:
PI3K/Akt/mTOR signaling|Cytoskeletal Signaling|Stem Cells
Purity:
0.98
SMILES:
Cl.Cl.Cl.Cc1cnc([nH]1)-c1cnc(NCCNc2ccc(cn2)C#N)nc1-c1ccc(Cl)cc1Cl
Target:
Wnt/beta-catenin|GSK-3

References

Ring DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. Ye S, et al. Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One. 2012;7(4):e35892. Bennett CN, et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem. 2002 Aug 23;277(34):30998-1004. Naujok O, et al. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.BMC Res Notes. 2014 Apr 29;7:273. Wang X, et al. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep. 2015 Apr 10;5:8566.