TargetMol

A 127722

Product Code:
 
TAR-T23590
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23590-5mg5mg£930.00
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TAR-T23590-50mg50mg£1,821.00
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Quantity:
TAR-T23590-100mg100mg£2,319.00
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This product comes from: United States.
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Further Information

Bioactivity:
A 127722 is a highly potent and selective ETA endothelin receptor antagonist (IC50: 0.11 nM and 98 nM for human ETA and ETB receptors, respectively).
CAS:
195704-72-4
Formula:
C29H38N2O6
Molecular Weight:
510.63
Purity:
0.98
SMILES:
O=C([C@H]1[C@H](C2=CC=C(OC)C=C2)N(CC(N(CCCC)CCCC)=O)C[C@@H]1C3=CC=C(OCO4)C4=C3)O

References

1. Winn et al (1996) 2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722. J.Med.Chem. 39 1039 PMID: 8676339 2. Opgenoth et al (1996) Pharmacological characterization of A-127722: an orally active and highly potent ETA-selective receptor antagonist. J.Pharmacol.Exp.Ther. 276 473 PMID: 8632312 3. Chen et al (1997) The orally active nonpeptide endothelin A-receptor antagonist A-127722 prevents and reverses hypoxia-induced pulmonary hypertension and pulmonary vascular remodeling in Sprague-Dawley rats. J.Cardiovasc.Pharmacol 29 713 PMID: 9234651