TargetMol

Dynapyrazole A

Product Code:
 
TAR-T35548
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35548-1mg1mg£95.00
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TAR-T35548-5mg5mg£128.00
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TAR-T35548-1mL1 mL * 10 mM (in DMSO)£132.00
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TAR-T35548-10mg10mg£168.00
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TAR-T35548-25mg25mg£279.00
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TAR-T35548-50mg50mg£426.00
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TAR-T35548-100mg100mg£597.00
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Further Information

Bioactivity:
Dynein inhibitor. Inhibits dynein 1 and dynein 2-dependent microtubule gliding (IC50 values are 2.3 and 2.6 μM, respectively). Inhibits hedgehog signaling in vitro (IC50 = 1.9 μM). Displays reversible inhibition of retrograde and anterograde intraflagellar transport in Chlamydomonas; displays stronger inhibition of retrograde transport.
CAS:
2226517-75-3
Formula:
C20H12ClIN4O
Molecular Weight:
486.7
Pathway:
Cytoskeletal Signaling
Purity:
0.98
SMILES:
ClC1=CC=C(C2(C3=NN4C(NC(C5=CC(I)=CC=C45)=O)=C3C#N)CC2)C=C1
Target:
Dynamin

References

Zhaoyang Jing, et al. Rotavirus Viroplasm Biogenesis Involves Microtubule-Based Dynein Transport Mediated by an Interaction between NSP2 and Dynein Intermediate Chain. J Virol. 2021 Oct 13;95(21):e0124621.