TargetMol

NO-Losartan A

Product Code:
 
TAR-T35600
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35600-5mg5mg£850.00
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Quantity:
TAR-T35600-50mg50mg£1,661.00
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Quantity:
TAR-T35600-100mg100mg£2,079.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor. Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM. In humans, losartan effectively controls hypertension while protecting renal function. Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium. NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.
CAS:
791122-48-0
Formula:
C30H28ClN7O5
Molecular Weight:
602
Purity:
0.98
SMILES:
CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N](=O)O)c2)n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1