TargetMol

GW 1929 hydrochloride

Product Code:
 
TAR-T37579
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37579-100mg100mg£915.00
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Further Information

Bioactivity:
Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo.
CAS:
1217466-21-1
Formula:
C30H29N3O4.HCl
Molecular Weight:
532.03
Purity:
0.98
SMILES:
Cl.CN(CCOC1=CC=C(C[C@H](NC2=CC=CC=C2C(=O)C2=CC=CC=C2)C(O)=O)C=C1)C1=NC=CC=C1

References

Brown et al (1999) A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-? reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 48 1415 PMID:10389847 Way et al (2001) Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor ? agonists. J.Biol.Chem. 276 25651 PMID:11373275 Nugent et al (2001) Potentiation of glucose uptake in 3T3-L1 adipocytes by PPAR? agonists is maintained in cells expressing a PPAR? dominant-negative mutant: evidence for selectivity in the downstream responses to PPAR? activation. Mol.Endocrinol. 15 1729 PMID:11579205