TargetMol

PF 04671536 hydrochloride

Product Code:
 
TAR-T37799
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37799-5mg5mg£850.00
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Quantity:
TAR-T37799-50mg50mg£1,661.00
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Quantity:
TAR-T37799-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Potent and selective PDE8B/8A inhibitor ( IC50 values are 1.3 and 1.9 nM, respectively). Exhibits selectivity for PDE8A/B over other PDEs (IC50 values are >10 μM) and a range of other targets. Increases glucose-dependent insulin secretion from human pacreatic islet cells. Orally bioavailable.
CAS:
1305116-67-9
Formula:
C14H18N8OS.HCl
Molecular Weight:
382.87
Purity:
0.98
SMILES:
CC1=NC(N)=C2N=NN(C2=N1)C[C@H]3CN(CCO3)CC4=NC=CS4.Cl

References

DeNinno et al (2012) Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes. Bioorg.Med.Chem.Lett. 22 5721 PMID:22858141