TargetMol

2?-O-(2-Methoxyethyl)guanosine

Product Code:
 
TAR-T40566
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
2?-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a 2?-O-methoxyethyl-modified nucleoside, can be produced by enzymatic conversion (adenosine deaminase) from 2?-O-(2-methoxyethyl)-2,6-diaminopurine riboside. 2?-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA.
CAS:
473278-54-5
Formula:
C13H19N5O6
Molecular Weight:
341.324
Purity:
0.98
SMILES:
COCCO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c1nc(N)[nH]c2=O

References

Saleh AF, et, al. 2'-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells. Toxicol Sci. 2018 May 1;163(1):70-78. McPherson AK, et, al. An Improved Process for the Manufacture of 5?-O-(4,4?-Dimethoxytrityl)-N2-isobutyryl-2?-O-(2-methoxyethyl)guanosine. Org. Process Res. Dev. 2020, 24, 11, 2583-2590.