TargetMol

TLK117

Product Code:
 
TAR-T8424
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
TLK117 selective inhibits Glutathione S-transferase P1?1 (GSTP1-1)(Ki of 0.4 μM for GSTP).
CAS:
152684-53-2
Formula:
C23H27N3O6S
Molecular Weight:
473.54
Purity:
0.98
SMILES:
N[C@@H](CCC(=O)N[C@@H](CSCc1ccccc1)C(=O)N[C@@H](C(O)=O)c1ccccc1)C(O)=O

References

McMillan DH, et al. Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase ?. JCI Insight. 2016 Jun 2;1(8). pii: e85717. The human glutathione transferase P1-1 specific inhibitor TER 117 designed for overcomingcytostatic-drug resistance is also a strong inhibitor of glyoxalase I. Mol Pharmacol. 2000 Mar;57(3):619-24.