TargetMol

Ibrutinib deacryloylpiperidine

Product Code:
 
TAR-T8636
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8636-100mg100mg£103.00
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Quantity:
TAR-T8636-1mL1 mL * 10 mM (in DMSO)£111.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T8636-200mg200mg£118.00
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This product comes from: United States.
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Further Information

Bioactivity:
Ibrutinib deacryloylpiperidine is a highly selective Bruton?s tyrosine kinase (BTK) irreversible inhibitor with an IC50 of 0.5 nM.
CAS:
330786-24-8
Formula:
C17H13N5O
Molecular Weight:
303.318
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.998
SMILES:
Nc3ncnc4nnc(c2ccc(Oc1ccccc1)cc2)c34
Target:
BTK

References

Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.