TargetMol

Indomethacin

Product Code:
 
TAR-T0458
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T0458-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T0458-1g1g£111.00
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Further Information

Bioactivity:
Indomethacin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.
CAS:
53-86-1
Formula:
C19H16ClNO4
Molecular Weight:
357.79
Pathway:
Autophagy; Neuroscience; Metabolism; Immunology/Inflammation
Purity:
0.9984
SMILES:
COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1
Target:
Phospholipase; COX; PDE; Autophagy

References

1. Dihlmann S, et al. Oncogene, 2001, 20(5), 645-653. 2. Hoehn BD, et al. Stroke, 2005, 36(12), 2718-2724. 3. Yamada T, et al. Inflammation, 1993, 17(6), 641-662. 4. Fischer SM, et al. Mol Carcinog, 1999, 25(4), 231-240. 5. Yoshikawa T, et al. Gut, 1993, 34(6), 732-737. 6. Lopes RS, et al. Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia. J Biosci. 2016 Sep;41(3):381-94. 7. Afroz S, et al. Concentrated phosphatidic acid in cereal brans as potential protective agents against indomethacin-induced stomach ulcer. J Agric Food Chem. 2016 Aug 26. 8. Qixiong Zhang, et al. Structure-Property Correlations of Reactive Oxygen Species-Responsive and Hydrogen Peroxide-Eliminating Materials with Anti-Oxidant and Anti-Inflammatory Activities. Chem Mater. 2017, 29(19):8221-8238. 9. Chen F, Xu Y, Wang J, et al. Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms[J]. Evidence-Based Complementary and Alternative Medicine. 2020, 2020.