TargetMol

PhiKan 083 hydrochloride

Product Code:
 
TAR-T16523
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
PhiKan 083 hydrochloride is a carbazole derivative. Which binds to the surface cavity and stabilizes Y220C (Kd: 167 μM). It also a relative binding affinity (Kd) of 150 μM in Ln229 cells.
CAS:
1050480-30-2
Formula:
C16H19ClN2
Molecular Weight:
274.79
Purity:
0.98
SMILES:
Cl.CCn1c2ccccc2c2cc(CNC)ccc12

References

1. Boeckler FM, et al. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5. 2. Rauf SM, et al. Effect of Y220C mutation on p53 and its rescue mechanism: a computer chemistry approach. Protein J. 2013 Jan;32(1):68-74. 3. Paulmurugan R, et al. A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells. Oncotarget. 2018 Apr 20;9(30):21495-21511.