TargetMol

Pyridoclax

Product Code:
 
TAR-T16694
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Pyridoclax is an inhibitor of potential Mcl-1.
CAS:
1651890-44-6
Formula:
C29H22N4
Molecular Weight:
426.523
Pathway:
Apoptosis
Purity:
0.98
SMILES:
Cc1cc(cnc1-c1cccnc1)-c1ncc(cc1C=Cc1ccccc1)-c1cccnc1
Target:
BCL

References

1. Gloaguen C, et al. First evidence that oligopyridines, ?-helix foldamers, inhibit Mcl-1 and sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies. J Med Chem. 2015 Feb 26;58(4):1644-68. 2. Groo AC, et al. Comparison of 2 strategies to enhance Pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis. Eur J Pharm Sci. 2017 Jan 15;97:218-226.