TargetMol

QX-314 bromide

Product Code:
 
TAR-T16707
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16707-5mg5mg£131.00
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TAR-T16707-50mg50mg£351.00
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TAR-T16707-100mg100mg£502.00
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This product comes from: United States.
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Further Information

Bioactivity:
QX-314 bromide is a blocker of the membrane-impermeable permanently charged sodium channel.
CAS:
24003-58-5
Formula:
C16H27BrN2O
Molecular Weight:
343.3
Pathway:
Membrane transporter/Ion channel
Purity:
0.98
SMILES:
O=C(NC1=C(C)C=CC=C1C)C[N+](CC)(CC)CC.[Br-]
Target:
Sodium Channel

References

1. Rivera-Acevedo RE, et al. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. Anesthesiology. 2011 Jun;114(6):1425-34. 2. Binshtok AM, et al. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology. 2009 Jul;111(1):127-37. 3. Talbot MJ, et al. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1996 Sep;76(3):2120-4.