TargetMol

TC-S 7009

Product Code:
 
TAR-T17009
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T17009-5mg5mg£122.00
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Quantity:
TAR-T17009-1mL1 mL * 10 mM (in DMSO)£127.00
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TAR-T17009-10mg10mg£168.00
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TAR-T17009-25mg25mg£269.00
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TAR-T17009-50mg50mg£366.00
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Quantity:
TAR-T17009-100mg100mg£507.00
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Quantity:
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Further Information

Bioactivity:
TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd 5 μM). TC-S 7009 is an effective and selective inhibitor of HIF-2α (Kd: 81 nM). TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression.
CAS:
1422955-31-4
Formula:
C12H6ClFN4O3
Molecular Weight:
308.65
Pathway:
Chromatin/Epigenetic; Angiogenesis
Purity:
0.98
SMILES:
[O-][N+](=O)c1c(Nc2cc(F)cc(Cl)c2)ccc2nonc12
Target:
HIF

References

Senavirathna LK, et al. Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Sci Rep. 2018;8(1):2709. Scheuermann TH, et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol. 2013;9(4):271-276.