TargetMol

Ansamitocin p-3

Product Code:
 
TAR-T22262
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22262-1mg1mg£111.00
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TAR-T22262-2mg2mg£130.00
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TAR-T22262-5mg5mg£168.00
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TAR-T22262-1mL1 mL * 10 mM (in DMSO)£209.00
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TAR-T22262-10mg10mg£213.00
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TAR-T22262-25mg25mg£306.00
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TAR-T22262-50mg50mg£402.00
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TAR-T22262-100mg100mg£510.00
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This product comes from: United States.
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Further Information

Bioactivity:
Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) is a potent tubulin polymerization inhibitor with IC50 of 3.4 μM.
CAS:
66584-72-3
Formula:
C32H43ClN2O9
Molecular Weight:
635.14
Pathway:
Cytoskeletal Signaling
Purity:
0.98
SMILES:
[H][C@@]12O[C@@]1(C)[C@H](CC(=O)N(C)c1cc(CC(C)=C/C=C[C@@H](OC)[C@@]3(O)C[C@]([H])(OC(=O)N3)[C@H]2C)cc(OC)c1Cl)OC(=O)C(C)C
Target:
Microtubule Associated

References

Venghateri JB, et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at thevinblastine site. PLoS One. 2013 Oct 4;8(10):e75182. Kiso T, et al. Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss. Antimicrob Agents Chemother. 2004 May;48(5):1739-48