TargetMol

Necrostatin-5

Product Code:
 
TAR-T37558
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37558-5mg5mg£104.00
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TAR-T37558-10mg10mg£124.00
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TAR-T37558-25mg25mg£189.00
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Quantity:
TAR-T37558-50mg50mg£245.00
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This product comes from: United States.
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Further Information

Bioactivity:
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-5 is a selective allosteric inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 240 nM.
CAS:
337349-54-9
Formula:
C19H17N3O2S2
Molecular Weight:
383.48
Pathway:
Apoptosis|NF-κb
Purity:
0.98
SMILES:
COc1ccc(cc1)-n1c(SCC#N)nc2sc3CCCCc3c2c1=O
Target:
Necroptosis|RIP kinase

References

Dmitriev YV, Minasian SM, Demchenko EA, Galagudza MM. Study of cardioprotective effects of necroptosis inhibitors on isolated rat heart subjected to global ischemia-reperfusion. Bull Exp Biol Med. 2013;155(2):245-248. Gonz?lez-Juarbe N, Gilley RP, Hinojosa CA, et al. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog. 2015;11(12):e1005337.