TargetMol

1-Dodecylimidazole

Product Code:
 
TAR-T37885
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37885-1mL1 mL * 10 mM (in DMSO)£106.00
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TAR-T37885-200mg200mg£115.00
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TAR-T37885-500mg500mg£130.00
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This product comes from: United States.
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Further Information

Bioactivity:
1-Dodecylimidazole (N-Dodecylimidazole) is a cytotoxic agent and a lysosomotropic detergent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity.
CAS:
4303-67-7
Formula:
C15H28N2
Molecular Weight:
236.403
Pathway:
Microbiology/Virology
Purity:
0.98
SMILES:
CCCCCCCCCCCCn1ccnc1
Target:
Antifungal

References

Atkin SD, et al. The isolation of 2,3-oxidosqualene from the liver of rats treated with 1-dodecylimidazole, a novel hypocholesterolaemic agent. Biochem J. 1972;130(1):153-157. Boyer MJ, et al. pH dependent cytotoxicity of N-dodecylimidazole: a compound that acquires detergent properties under acidic conditions. Br J Cancer. 1993;67(1):81-87. Firestone RA, et al. Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents. J Med Chem. 1987;30(8):1519-1521. Wilson PD, et al. A relationship between multidrug resistance and growth-state dependent cytotoxicity of the lysosomotropic detergent N-dodecylimidazole. Biochem Biophys Res Commun. 1991;176(3):1377-1382.