TargetMol

Triamcinolone

Product Code:
 
TAR-T0798
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0798-500mg500mg£107.00
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Quantity:
TAR-T0798-1mL1 mL * 10 mM (in DMSO)£111.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
Triamcinolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to translocation of the ligand-receptor complex to the nucleus and induces expression of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, pro-inflammatory cytokine production, including interleukin (IL)-1and IL-6, and the activation of cytotoxic T-lymphocytes is also inhibited. T-cells are prevented from making IL-2 and proliferating. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis through increasing Ikappa-B expression and curtailing activation of nuclear factor (NF)kappa-B.
CAS:
124-94-7
Formula:
C21H27FO6
Molecular Weight:
394.44
Pathway:
Neuroscience; Immunology/Inflammation; Endocrinology/Hormones
Purity:
0.9954
SMILES:
C[C@@]12[C@](C(=O)CO)(O)[C@H](O)C[C@H]1[C@@H]1CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C2
Target:
Glucocorticoid Receptor; COX

References

1. Schaefer EC, et al. Am J Vet Res. 2009 Dec;70(12):1494-501.