TargetMol

Busulfan

Product Code:
 
TAR-T0923
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0923-500mg500mg£107.00
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Quantity:
TAR-T0923-1mL1 mL * 10 mM (in DMSO)£111.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T0923-1g1g£120.00
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This product comes from: United States.
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Further Information

Bioactivity:
Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription.
CAS:
55-98-1
Formula:
C6H14O6S2
Molecular Weight:
246.29
Pathway:
DNA Damage/DNA Repair; Apoptosis
Purity:
0.9977
SMILES:
CS(=O)(=O)OCCCCOS(C)(=O)=O
Target:
Apoptosis; DNA Alkylator/Crosslinker; DNA Alkylation

References

1. Meng A, et al. Cancer Res, 2003, 63(17), 5414-5419. 2. Probin V, et al. Free Radic Biol Med, 2007, 42(12), 1858-1865. 3. Choi YJ, et al. FEBS Lett, 2004, 575(1-3), 41-51. 4. Robert-Richard E, et al. Haematologica, 2006, 91(10), 1384. 5. Yeager AM, et al. Blood, 1991, 78(12), 3312-3316.