TargetMol

Defactinib hydrochloride

Product Code:
 
TAR-T15092
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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This product comes from: United States.
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Further Information

Bioactivity:
Defactinib hydrochloride is a novel inhibitor of FAK which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.
CAS:
1073160-26-5
Formula:
C20H22ClF3N8O3S
Molecular Weight:
546.95
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling
Purity:
0.98
SMILES:
Cl.CNC(=O)c1ccc(Nc2ncc(c(NCc3nccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
Target:
FAK

References

Kang Y, et al. Role of focal adhesion kinase in regulating YB-1-mediated resistance in ovarian cancer. J Natl Cancer Inst. 2013 Oct 2;105(19):1485-95.