TargetMol

Chlorin e6

Product Code:
 
TAR-T36466
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36466-10mg10mg£95.00
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TAR-T36466-1mL1 mL * 10 mM (in DMSO)£99.00
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TAR-T36466-25mg25mg£106.00
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TAR-T36466-50mg50mg£122.00
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TAR-T36466-100mg100mg£155.00
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Further Information

Bioactivity:
Chlorin e6 (Ce6) is a second-generation photosensitizer with antitumor activity when used in conjunction with irradiation. In a mouse model of implanted fibrosarcoma, Ce6 (2.5-10 mg/kg, i.v. with irradiation at 50-200 J/cm2) led to complete tumor loss following varying levels of irradiation.[1] A formulation including Ce6 was tested in a Phase I clinical study for patients with bronchogenic early superficial squamous cell carcinoma with positive results (40 mg/m2, i.v. with laser irradiation at 100 J/cm2).[2] The same dosing paradigm in a Phase II clinical trial for early stage lung cancer patients led to a complete response in 82.9% of patients.[3] Ce6 has been examined as a nanotechnology drug delivery tool.[4]
CAS:
19660-77-6
Formula:
C34H36N4O6
Molecular Weight:
596.684
Pathway:
Microbiology/Virology
Purity:
0.98
SMILES:
CCc1c(C)c2cc3[nH]c(cc4nc([C@@H](CCC(O)=O)[C@@H]4C)c(CC(O)=O)c4[nH]c(cc1n2)c(C)c4C(O)=O)c(C)c3C=C
Target:
Parasite

References

Nishie H,et al. Excellent antitumor effects for gastrointestinal cancers using photodynamic therapy with a novel glucose conjugated chlorin e6. Biochem Biophys Res Commun. 2018;496(4):1204-1209. Merlin JL, et al. The multidrug resistance modulator SDZ-PSC 833 potentiates the photodynamic activity of chlorin e6 independently of P-glycoprotein in multidrug resistant human breast adenocarcinoma cells. Int J Oncol. 2003;22(4):733-739. Pinto JG, et al. Chlorin E6 phototoxicity in L. major and L. braziliensis promastigotes-In vitro study [published correction appears in Photodiagnosis Photodyn Ther. 2017 Dec;20:287]. Photodiagnosis Photodyn Ther. 2016;15:19-24. Akhlynina TV, et al. Nuclear targeting of chlorin e6 enhances its photosensitizing activity. J Biol Chem. 1997;272(33):20328-20331.