TargetMol

5-Aminovaleric acid

Product Code:
 
TAR-T5089
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T5089-500mg500mg£120.00
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TAR-T5089-1g1g£140.00
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Further Information

Bioactivity:
5-aminovalerate (or 5-aminopentanoic acid) is a lysine degradation product. It can be produced both endogenously or through bacterial catabolism of lysine. 5-aminovalerate is formed via the following multi-step reaction: L-lysine leads to cadverine leads to L-piperideine leads 5-aminovalerate . In other words it is a metabolite of cadaverine which is formed via the intermediate, 1-piperideine. Cadaverine is a foul-smelling diamine compound produced by protein hydrolysis during putrefaction of animal tissue. High levels of 5-aminovalerate in biofluids may indicate bacterial overgrowth or endogenous tissue necrosis. In most cases endogenous 5-aminovalerate is thought to be primarily a microbial metabolite produced by the gut or oral microflora, although it can be produced endogenously. 5-aminopentanoic acid is an in vivo substrate of 4-aminobutyrate:2-oxoglutarate aminotransferase .
CAS:
660-88-8
Formula:
C5H11NO2
Molecular Weight:
117.148
Pathway:
; Metabolism
Purity:
0.98
SMILES:
NCCCCC(O)=O
Target:
Endogenous Metabolite

References

Fothergill J C , Guest J R . Catabolism of l-Lysine by Pseudomonas aeruginosa[J]. Journal of General Microbiology, 1977, 99(1):139-55. Callery P S , Geelhaar L A . Biosynthesis of 5-Aminopentanoic Acid and 2-Piperidone from Cadaverine and 1-Piperideine in Mouse [J]. Journal of Neurochemistry, 1984, 43(6):4. Callery P S , Geelhaar L A . 1-Piperideine as an in vivo precursor of the gamma-aminobutyric acid homologue 5-aminopentanoic acid[J]. Journal of Neurochemistry, 2010, 45(3):946-948. Santos A , Zanetta S , Cresteil T , et al. Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans[J]. Clinical Cancer Research, 2000, 6(5):2012-2020. Cole K R , Castellino F J . The binding of antifibrinolytic amino acids to kringle-4-containing fragments of plasminogen[J]. Archives of Biochemistry & Biophysics, 1984, 229(2):568-575.