TargetMol

4-Phenylbutyric acid

Product Code:
 
TAR-T5886
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5886-500mg500mg£103.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T5886-1mL1 mL * 10 mM (in DMSO)£111.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Benzenebutyric acid is an inhibitor of HDAC,and is an antineoplastic agent.
CAS:
1821-12-1
Formula:
C10H12O2
Molecular Weight:
164.204
Pathway:
Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
Purity:
0.9976
SMILES:
OC(=O)CCCc1ccccc1
Target:
Virus Protease; HDAC

References

Gon?alo Frouco, Freitas F B , Martins C , et al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14[J]. Virus Research, 2017, 242:24-29. Tsg-Hui C , Eva S . Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung[J]. Clinical Cancer Research, 2002, 8(4):1206-1212. Wang H, Chen J, Bai G, et al. mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4 + T Cell Apoptosis Mediated by ROS in Septic Immunosuppression. Mediators of Inflammation. 2022 Dong L, Xu M, Li Y, et al.SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway.Cell Death & Disease.2023, 14(6): 361. Yu Y, Wu T, Zhang X, et al.Regorafenib activates oxidative stress by inhibiting SELENOS and potentiates oxaliplatin-induced cell death in colon cancer cells.European Journal of Pharmacology.2023: 175986.