Collinolactone
Product Code:
BVT-0480
BVT-0480
Regulatory Status:
RUO
RUO
Shipping:
AMBIENT
AMBIENT
Storage:
Short term: +4°C. Long term: -20°C
Short term: +4°C. Long term: -20°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| BVT-0480-C250 | 250 ug | £180.00 |
Quantity:
| BVT-0480-M001 | 1 mg | £525.00 |
Quantity:
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* Rare exceptions are clearly labelled (only 0.14% of items!).
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This product comes from: Switzerland.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
- Further Information
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Further Information
Alternate Names/Synonyms:
Rhizolutin
Appearance:
White to off-white solid.
CAS:
2733581-46-7
EClass:
32160000
Form (Short):
solid
Handling Advice:
Keep cool and dry. Protect from light when in solution.
InChi:
InChI=1S/C21H28O5/c1-4-16-11-17-13(3)8-19-14(9-15(22)10-20(23)26-19)6-5-12(2)7-18(17)21(24)25-16/h5-8,14-19,22H,4,9-11H2,1-3H3/b6-5+,12-7-,13-8+/t14-,15-,16+,17-,18-,19-/m0/s1
InChiKey:
GSVYLEFSSDOSSC-QHEHVBGPSA-N
Long Description:
Chemical. CAS: 2733581-46-7. Formula: C21H28O5. MW: 360.45. Collinolactone has neuroprotective and anti-neurodegenerative effects by reducing intracellular oxidative stress. It protects against glutamate-induced oxidative stress in a dose-dependent manner. Collinolactone is a potential anti-Alzheimer agent with Aβ-disaggregating activity. It showed dissociative effect on Aβ aggregates and tau tangles in vitro, with significantly reduced apoptosis and inflammation in neuronal and glial cells. In vivo studies on APP/PS1 double transgenic mice showed substantially dissociated hippocampal plaques. A set of semisynthetic collinolactone analogs (but not collinolactone) has shown inhibitory effects on a L929 cell line.
Molecular Formula:
C21H28O5
Molecular Weight:
360.45
Package Type:
Vial
Product Description:
Collinolactone has neuroprotective and anti-neurodegenerative effects by reducing intracellular oxidative stress. It protects against glutamate-induced oxidative stress in a dose-dependent manner. Collinolactone is a potential anti-Alzheimer agent with Aβ-disaggregating activity. It showed dissociative effect on Aβ aggregates and tau tangles in vitro, with significantly reduced apoptosis and inflammation in neuronal and glial cells. In vivo studies on APP/PS1 double transgenic mice showed substantially dissociated hippocampal plaques. A set of semisynthetic collinolactone analogs (but not collinolactone) has shown inhibitory effects on a L929 cell line.
Product Line Areas NEW:
Biochemicals, Natural Products, Drug Discovery, Immunology, Inflammation, Neurobiology, Neurodegenerative Disease, Oxidative Stress
Product Type:
Chemical
Purity:
>98% (HPLC)
SMILES:
O=C1O[C@H](CC)C[C@]2([H])[C@]1([H])/C=C(C)C=C[C@](C[C@H](O)CC(O3)=O)([H])[C@]3([H])/C=C2C
Solubility Chemicals:
Soluble in DMSO, pyridine, toluene, benzene or acetonitrile. Insoluble in water. We recommend to avoid solutions in methanol. Protect from pH-values below pH 4.0 and above pH 8.0.
Source / Host:
Isolated from Streptomyces sp.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
Documents
References
Big effects from small changes: possible ways to explore nature's chemical diversity: H.B. Bode, et al.; Chembiochem 3, 619 (2002) | Rhizolutin, a novel 7/10/6-tricyclic dilactone, dissociates misfolded protein aggregates and reduces apoptosis/inflammation associated with Alzheimer's Disease: Y. Kwon, et al.; Angew. Chem. Int. Ed. 59, 22994 (2020) | Structure of cyclodecatriene collinolactone, its biosynthesis, and semisynthetic analogues: effects of monoastral phenotype and protection from intracellular oxidative stress: J.C. Schmid, et al.; Angew. Chem. Int. Ed. 60, 23212 (2021)