AdipoGen Life Sciences

TG007

Product Code:
 
AG-CR1-3666
Product Group:
 
Other Biochemicals
Regulatory Status:
 
RUO
Shipping:
 
AMBIENT
Storage:
 
Short term: +4°C. Long term: -20°C
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Chemical Structure
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Chemical Structure

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AG-CR1-3666-M0055 mg£85.00
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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
(Z)-3-Ethyl-2-(2-oxopropylidene)-2,3-dihydrobenzo[d]thiazol-5-yl acetate; ProINDY
Appearance:
White to off-white solid.
CAS:
719277-30-2
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C14H15NO3S/c1-4-15-12-8-11(18-10(3)17)5-6-13(12)19-14(15)7-9(2)16/h5-8H,4H2,1-3H3/b14-7-
InChiKey:
RLEOCVDWLAYGRX-AUWJEWJLSA-N
Long Description:
Chemical. CAS: 719277-30-2. Formula: C14H15NO3S. MW: 277.3. Synthetic. Prodrug form (acetylated derivative) of INDY (Prod. No. AG-CR1-3665). Cell permeable ATP-competitive DYRK1A and DYRK1B inhibitor. Inhibits phosphorylation of Tau-protein and rescues repressed calcineurin/NFAT signaling. Recovers Xenopus embryos from head malformation induced by DYRK1A overexpression in vivo.
MDL:
MFCD27937773
Molecular Formula:
C14H15NO3S
Molecular Weight:
277.3
Package Type:
Plastic Vial
Precautions:
P302, P352, P304, P340, P305, P351, P338
Product Description:
Prodrug form (acetylated derivative) of INDY (Prod. No. AG-CR1-3665). Cell permeable ATP-competitive DYRK1A and DYRK1B inhibitor. Inhibits phosphorylation of Tau-protein and rescues repressed calcineurin/NFAT signaling. Recovers Xenopus embryos from head malformation induced by DYRK1A overexpression in vivo.
Purity:
>98% (HPLC)
Signal Word:
Warning
SMILES:
O=C(C)/C=C1SC2=CC=C(OC(C)=O)C=C2N1CC
Solubility Chemicals:
Soluble in DMSO (10mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A: Y. Ogawa, et al.; Nat. Commun. 1, 86 (2010)