Leinco Technologies

Anti-Human Caspase-3 Active Subunit (p17)

Product Code:
 
LEI-C1141
Product Group:
 
Primary Antibodies
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
C31.129
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
2-8°C
Storage:
 
This purified antibody is stable when stored at 2-8°C. Do not freeze.
 

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CodeSizePrice
LEI-C1141-0.2mg0.2 mg£313.00
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This product comes from: US.
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  • Further Information
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Further Information

Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified
Format:
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Long Description:
Caspase-3 is a member of the caspase family of cysteine proteases and plays a key role in mediating Fas (CD95) and tumor necrosis factor?1 (TNFR-1) induced apoptosis. Caspases can be divided into three groups: apoptotic initiators, apoptotic executioners, and inflammatory mediators.1,2 Caspase-3 is activated during apoptotic signaling events by upstream proteases including caspase 6 and caspase 8.3 Caspase-3 is thought to be essential for chromatin margination, DNA fragmentation and nuclear collapse during apoptosis.3
Target:
Caspase-3 Active Subunit (p17)

References

1. Adadah, BA. et al. (2000) Journal of Neurotoma 17(10): 811 2. Salvesen, GS. et al. (1999) Proc. Natl. Acad. Sci. USA 96(20): 10964 3. Slee, EA. et al. (2001) J. Biol. Chem. 276(10):7320