Leinco Technologies

Recombinant Human Glial Cell Line-Derived Neurotrophic Factor (GDNF)

Product Code:
 
LEI-G120
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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CodeSizePrice
LEI-G120-10ug10 ug£307.00
Quantity:
LEI-G120-100ug100 ug£915.00
Quantity:
LEI-G120-500ug500 ug£4,181.00
Quantity:
LEI-G120-1mg1 mg£6,906.00
Quantity:
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Glial cell line-derived neurotrophic factor (GDNF), also known as ATF-1, is a glycosylated, disulfide-bonded homodimer and member of the TGF-β superfamily (1). It is structurally related to artemin, neurturin and persephin. GDNF potently promotes the survival of many types of neurons, most prominently, dopaminergic and motorneurons. It also regulates kidney development, spermatogenesis and it affects alcohol consumption (2). GDNF is expressed in Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells. It signals through a multicomponent receptor system composed of a RET oncogene and one of the four GFR-α receptors (3). GDNF protects and repairs dopamine-containing neurons, which degenerate in Parkinson's disease, and motor neurons, which die in amyotrophic lateral sclerosis. The use of GDNF in the treatment of Parkinson's disease has shown promise in the clinic by improving symptoms such as bradykinesia, rigidity and postural instability (4). Treatment of spinal cord injuries with GDNF has also produced neurological improvement.
NCBI Gene:
2668
Purity:
>98% by SDS-PAGE and HPLC
Target:
Glial-Derived Neurotrophic Factor

References

1. Collins, F. et al. (1993) Science 260:1130 2. Ron, D. et al. (2008) Proc. Natl. Acad. Sci. (USA) 105:8114 3. Wang, C. Y. et al. (1998) Neuroscience 83:7 4. Kirik, D. et al. (2004) Nature Neuro. 7:105