Leinco Technologies

Recombinant Human GM-CSF

Product Code:
 
LEI-G124
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This protein is stable for up to twelve months when stored at -20°C to -70°C. After thawing and addition of a carrier protein this protein may be stored at 2°C to 8°C for one month or for long-term storage aliquot and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
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CodeSizePrice
LEI-G124-10ug10 ug£420.00
Quantity:
LEI-G124-50ug50 ug£1,217.00
Quantity:
LEI-G124-500ug500 ug£2,765.00
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This product comes from: US.
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Further Information

Format:
This recombinant protein solution was 0.2 um filtered and formulated in modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Formulation:
This recombinant protein solution was 0.2 um filtered and formulated in modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Long Description:
Granulocyte-Macrophage Colony Stimulating Factor is a 22 kD, pleiotropic cytokine that is a white blood cell growth factor. It controls the production and function of blood cells by stimulating stem cells to produce granulocytes and monocytes. GM-CSF differs from G-CSF in that it affects more cell types including macrophages and eosinophils. Moreover, GM-CSF is part of the immune/inflammatory cascade, a process crucial for fighting infection. Interestingly, GM-CSF expression may have pathological implications. Autocrine expression of GM-CSF in myeloid leukemia cells is suspected to play a role in neoplasia, the formation of a new and abnormal growth of tissue. Additionally, GM-CSF expression has also been documented in certain solid tumors. There have also been reports of GM-CSF in synovial fluid from patients with arthritis suggesting that GM-CSF may play a role in tissue damage associated with the inflammatory process. Blocking GM-CSF is thought to have therapeutic potential by reducing inflammation. Some drugs are currently being developed to block GM-CSF.
NCBI Gene:
1437
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
GM-CSF

References

1. Parker, MW. et al. (2008) Cell 134:496 2. Esnault, S. et al. (2002) Arch. Immunol. Ther. Exp. (Warsz.) 50:121 3. Yong, KL. et al. (1993) J. Immunol. 150:2449 4. Whitsett, JA. et al. (2002) Annu. Rev. Physiol. 64:775 5. Armitage, JO. et al. (1992) Sem. Hematol. 29:14 6. Eksioglu, EA. et al. (2007) Exp. Hematol. 35:1163