Leinco Technologies

Recombinant Human IL-8

Product Code:
 
LEI-I-190
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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CodeSizePrice
LEI-I-190-10ug10 ug£318.00
Quantity:
LEI-I-190-50ug50 ug£682.00
Quantity:
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This product comes from: US.
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Further Information

Format:
This recombinant protein was lyophilized from a 0.2 um filtered solution in deionized water.
Formulation:
This recombinant protein was lyophilized from a 0.2 um filtered solution in deionized water.
Long Description:
Interleukin 8 (IL-8), also known as CXCL8, is a member of the CXC chemokine family. It is secreted by a variety of cell types including monocytes, macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL-1, TNF, LPS) (1). It is also synthesized by endothelial cells, which store IL-8 in vesicles. IL-8 functions as a chemoattractant for neutrophils, basophils, and T cells, but not monocytes (2). It also plays a vital role in tumorigenesis, progression and metastasis, and accordingly the expression levels of IL-8 correlate with disease progression in several human carcinomas (3). IL-8 has the N-terminal tripeptide ELR motif, which is known to mediate IL-8 receptor binding and subsequent signal transduction, such as the TRAF6-NF-κB pathway. It can also signal through the CXCR1 and CXCR2 receptors. IL-8 is believed to play a role in the pathogenesis of cystic fibrosis (4).
NCBI Gene:
3576
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
Interleukin-8

References

1. Baggiolini, M. et al. (1992) FEBS Lett. 307:97 2. K?hidai, L. et al. (1998) Cytokine 10:481 3. Yuan, A. et al. (2006) Front. Biosci. 10:853 4. Tabary, O. et al. (1998) Amer. J. Pathol. 153:921