Leinco Technologies

Recombinant Human M-CSF

Product Code:
 
LEI-M155
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Dry Ice
Storage:
 
Working aliquots of this recombinant protein solution are stable for up to twelve months at -20°C to -70°C in a manual defrost freezer. Upon thawing in the presence of a carrier protein this recombinant protein can be stored at 2° - 8°C for one month without detectable loss of activity. For long-term storage aliquot and freeze at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles.
 

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CodeSizePrice
LEI-M155-5ug5 ug£346.00
Quantity:
LEI-M155-10ug10 ug£448.00
Quantity:
LEI-M155-25ug25 ug£847.00
Quantity:
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This product comes from: US.
Typical lead time: 14-21 working days.
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Further Information

Format:
This recombinant protein solution was 0.2 um filtered and formulated in modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Formulation:
This recombinant protein solution was 0.2 um filtered and formulated in modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Long Description:
Macrophage colony-stimulating factor (M-CSF), also known as CSF-1, is a secreted cytokine and key regulator of cellular proliferation, differentiation and survival of blood monocytes, tissue macrophages and their progenitor cells. It is produced by monocytes, fibroblasts and endothelial cells and binds to the CSF-1 receptor, also known as CD115. It enhances cytotoxicity, superoxide production, phagocytosis, chemotaxis and secondary cytokine production in monocytes and macrophages (1). M-CSF also primes macrophage killing of tumor cells and microorganisms and stimulates pinocytosis. It is known as one of the factors essential for osteoclast development (2). M-CSF has been shown to play important roles in modulating dermal thickness and growth of the decidua and placenta during pregnancy (3). It is clinically used in the treatment of infection, malignancies and atherosclerosis, as well as, facilitating hematopoietic recovery after bone marrow transplantation (4).
NCBI Gene:
1435
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
M-CSF

References

1. Nemunaitis, J. et al. (1998) Clin. Infect. Dis. 26:1279 2. Ko, JS. et al. (2002) Exp. Mol. Med. 34:3403. Makrigiannakis, A. et al. (2006) Trends Endicrinol. Metab. 17:1784. Van de Pol, CJ. et al. (1991) Biotechnol. Therap. 2:231