Leinco Technologies

Recombinant Human B7-H2

Product Code:
 
LEI-B537
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
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LEI-B537-100ug100 ug£580.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
B7-H2, also known as ICOSL and B7RP-1, is a transmembrane glycoprotein and member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. B7-H2 is expressed on B cells and macrophages and binds to ICOS on activated T cells delivering a positive co-stimulatory signal for optimal T cell function (1). The structural features of B7-H2 are crucial for its co-stimulatory function where receptor binding is mediated solely by the IgV domain but requires the IgC domain for maintaining the structural integrity of the protein (2).
NCBI Gene:
23308
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
B7 Homolog 2

References

1. Wiendl, H. et al. (2003) Brain 126:10262. Yoshinaga, SK. et al. (1999) Nature 402:8273. Chattopadhyay, KJ. et al. (2006) Immunol. 177:3920