Leinco Technologies

Recombinant Rat Growth Hormone Receptor

Product Code:
 
LEI-G644
Product Group:
 
Recombinant Proteins
Host Type:
 
Rat
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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LEI-G644-50ug50 ug£648.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Growth hormone receptor, also known as GHR is a 55 kDa transmembrane receptor and a member of the class I cytokine receptor family. Biologically active growth hormone binds to GHR, which dimerizes to activate an intracellular signal transduction pathway leading to synthesis and secretion of IGF1. In plasma, IGF1 binds to the soluble IGF1 receptor (IGF1R). At target cells, this complex activates signal-transduction via the JAK/STAT pathway, which results in the mitogenic and anabolic responses that lead to growth (1). GHR has also been shown to interact with SGTA, PTPN11 and CISH (2-4). Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature (proportional dwarfism) (5).
NCBI Gene:
25235
Purity:
>90% by SDS-PAGE and analyzed by silver stain.
Target:
GHR

References

1. Goffin, V. et al. (1996) Endocrine Rev. 17:385 2. Schantl, J. et al. (2003) Biochem. J. ,/i> 373: 85 3. Stofega, MR. et al. (2000) Mol. Endocrinol. 14:1338 4. Ram, PA. et al. (1999) J. Biol. Chem. 274:35553 5. Laron, Z. et al. (2004) J. Clin. Endocrinol. Metab. 89:1031