Leinco Technologies

Recombinant Mouse IL-17F

Product Code:
 
LEI-I-531
Product Group:
 
Recombinant Proteins
Host Type:
 
Mouse
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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LEI-I-531-25ug25 ug£614.00
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Further Information

Format:
This recombinant protein was lyophilized from a 0.2 um filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Formulation:
This recombinant protein was lyophilized from a 0.2 um filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Long Description:
IL-17F, also known as C87042, is a homodimeric protein that is a member of the IL-17 family of cytokines produced by activated T cells and monocytes (1). IL-17F can stimulate production of other cytokines such as IL-6, IL-8 and G-CSF as well as regulate cartilage matrix turnover by increasing matrix release and inhibiting new matrix synthesis (2). It is an important regulator of inflammatory responses that functions differently than IL-17 in immune responses and diseases (3). IL-17F inhibits the angiogenesis of endothelial cells and induces endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1 (4). Skin biopsy samples from psoriasis patients show the upregulation of IL-17F expression (5).
NCBI Gene:
NP_665855
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
IL-17F

References

1. Starnes, T. et al. (2001) J. Immonol. 167:4137 2. Starovasnik, MA. et al. (2001) Embo. J. 20:5332 3. Dong, C. et al. (2008) J. Exp. Med. 205:1063 4. Starnes, T. et al. (2001) J. Immunol. 167:4137 5. Watanabe, H. et al. (2009) J. Invest. Dermatol. 129:650