Leinco Technologies

Recombinant Human CD120b (TNFR2) (aa 24-206)

Product Code:
 
LEI-T522
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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LEI-T522-25ug25 ug£614.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
TNF RII, also known as TNFRSF1B, is a transmembrane glycoprotein and member to the TNF receptor superfamily (1). It is limited primarily to hematopoietic cells and cells of the immune system and is produced naturally as a soluble form (sTNF RII) in various biological fluids (2). The soluble TNF receptor can bind TNF with high affinity and function as a TNF antagonist (3, 4). TNF RII is strongly expressed at the cartilage?pannus junction and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (1, 5). High plasma levels of sTNF RII were associated with increased incidence of coronary heart disease, independent of established cardiovascular risk factors (5). TNF RII has also been implicated in diabetes (6).
NCBI Gene:
7133
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
TNF RII

References

1. Dieud?, P. et al. (2002) Arthritis Care & Res. 46:2039 2. Ziegenhagen, MW. et al. (2000) J. Int. Med. 248:33 3. Chen, G. et al. (2002) Science 296:1634 4. Chung, A. et al. (2005) Mol. and Cell Biol. 25:4716 5. Wassink, TH. et al. (2000) Mol. Psych. 5:678 6. Shai, I. et al. (2005) Diabetes Care 28:1376