MBL

Anti-CD170 (Siglec-5) (Mouse) mAb-FITC

Product Code:
 
MBL-M096-4
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rat
Antibody Isotype:
 
IgG2b
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
8D2
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Flow Cytometry
  • Immunoprecipitation (IP)
Shipping:
 
4°C
Storage:
 
4°C
 

No additional charges, what you see is what you pay! *

CodeSizePrice
MBL-M096-450 ug (10-20 Assays)£301.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Applications:
IP - 2 ug/300 uL of cell extract from 5x106 cells FCM - 25 ug/mL (final concentration)
Background:
SiglecE (sialic acid-binding immunoglobulin-like lectin E/SigLec5/CD170) is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. SiglecE is expressed on neutrophil and monocyte populations, both in the blood and bone marrow, as a dimeric, disulfide linked, 140 kDa type I membrane protein containing cytoplasmic immune receptor-based tyrosine signaling motifs. SiglecE recruits the SH2-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2, which block signal transduction through dephosphorylation of signaling molecules. Thus SiglecE acts as an inhibitory receptor for ligand induced tyrosine phosphorylation.
Concentration:
50 ug/ml
Conjugate:
FITC
Formulation:
50 ug IgG in 1 mL PBS containing 1% BSA and 0.09% NaN3.
Gene IDs:
Human: 8778 Mouse: 83382
Immunogen Translated:
L cells transfected with mouse CD170
Reactivity:
This antibody reacts with mouse SiglecE on Flow cytometry.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma (clone 8D2) supernatant using protein G agarose. This hybridoma was established by fusion of mouse myeloma cell P3U1 with Wister rat lymph node immunized with mouse SiglecE transfected L cell.
Target:
Siglec-E/CD170

Documents

References

1) Zhang, J.Q., et al., Eur. J. Immunol. 34, 1175-1184 (2004)