Elabscience

Recombinant Human PVRL2/Nectin-2/CD112 (C-mIgG2a Fc)

Product Code:
 
PKSH034051
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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PKSH034051-10ug10ug£160.00
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PKSH034051-50ug50ug£327.00
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This product comes from: China.
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Further Information

Abbreviation:
PVRL2;Nectin-2;CD112
Accession:
Q92692-2
Background:
CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region. The V domain is believed to mediate nectin binding to its ligands. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), involving in cell to cell spreading of these viruses. It does not bind poliovirus. As a homophilic adhesion molecule, CD112 is found concentrated in adherens junctions, and exists on neurons, endothelial cells,epithelial cells and fibroblasts. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 mediates cytotoxicity and cytokine secretion by T and NK cells. The costimulatory responses may be a critical component in allergic reactions and may therefore become targets for anti-allergic therapy.
Calculated MW:
62.6 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-mIgG2a Fc
ObservedMW:
80-90 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Gln32-Leu360
Target Synonym:
Poliovirus Receptor-Related Protein 2;Herpes Virus Entry Mediator B;Herpesvirus Entry Mediator B;HveB;Nectin-2;CD112;PVRL2;HVEB;PRR2
UNIProt ID:
Q92692

Documents