Elabscience

SKP2 Polyclonal Antibody

Product Code:
 
E-AB-65710
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Western blot analysis of extracts of various cell lines using SKP2 Polyclonal Antibody at 1:500 dilution.
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Immunofluorescence analysis of U2OS cells using SKP2 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
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Western blot analysis of extracts of various cell lines using SKP2 Polyclonal Antibody at 1:500 dilution.
Immunofluorescence analysis of U2OS cells using SKP2 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

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E-AB-65710-60uL60uL£210.00
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E-AB-65710-120uL120uL£291.00
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E-AB-65710-200uL200uL£431.00
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This product comes from: China.
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Further Information

Abbreviation:
SKP2
Background:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Calculated MW:
23kDa/46kDa/47kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000,IF 1:50-1:200
Immunogen:
A synthetic peptide of human SKP2
ObservedMW:
48KDa
Purification method:
Affinity purification
Target Synonym:
SKP2;FBL1;FBXL1;FLB1;p45
UNIProt ID:
Q13309

Documents