Elabscience

Recombinant Human BDNF Protein (with pro peptide)(Active)

Product Code:
 
PKSH033559
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
 

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CodeSizePrice
PKSH033559-10ug10ug£180.00
Quantity:
PKSH033559-50ug50ug£378.00
Quantity:
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Abbreviation:
BDNF
Accession:
P23560
Activity:
Immobilized Human pro-BDNF at 2ug/ml(100 ul/well) can bind Human TrkB-His(Cat: PKSH033579). The ED50 of Human pro-BDNF is 1. 4 ug/ml.
Background:
The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis; whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival; growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects; Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
Calculated MW:
25.6 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
E.coli
Formulation:
Supplied as a 0.2 um filtered solution of 20mM PB, 10% Trehalose, 100mM NaCl, 0.02% Tween 80, pH 6.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
None
ObservedMW:
28 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Ala19-Arg247(R125A,R127A,R128A)
Target Synonym:
Brain-Derived Neurotrophic Factor;BDNF;Abrineurin
UNIProt ID:
P23560

Documents