Recombinant Human RNASET2 Protein (Human Cells, His Tag)

RNASET2

O00584

RNASET2 (ribonuclease T2) is an enzyme which belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. This protein can be inhibited by Zn2+ and Cu2+. It has ribonuclease activity, with higher activity at acidic pH and is probably involved in lysosomal degradation of ribosomal RNA. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.

28.2 kDa

< 1.0 EU per ug of the protein as determined by the LAL method.

HEK293 Cells

Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl,20%Glycerol,pH7.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

C-His

40 kDa

> 95 % as determined by reducing SDS-PAGE.

Asp25-His256

Ribonuclease T2;3.1.27.-;Ribonuclease 6;RNASE6PL

O00584