Recombinant Mouse Interleukin-21/IL-21 Protein (His Tag)

Interleukin-21;IL-21

Q9ES17

Interleukin-21(IL-21) is an approximately 14 kDa cytokine which belongs to the IL-15/IL-21 family. Mature mouse IL-21 shares 66%,59%, 58%, and 88% aa sequence identity with mature canine, human, rabbit, and rat IL-21, respectively. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex (IL-21 specific IL-21 R). IL-21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. This cytokine induces cell division/proliferation in its target cells. It is required for the migration of dendritic cells to draining lymph nodes .It co-stimulates the activation, proliferation, and survival of CD8+ T cells and NKT cells and promotes Th17 cell polarization. It blocks the generation of regulatory T cells and their suppressive effects on CD4+ T cells.

16.5 kDa

< 1.0 EU per ug of the protein as determined by the LAL method.

E.coli

Lyophilized from a 0.2 um filtered solution of 20mM Histidine-HCl, 6% Sucrose, 2% Glycine, 50mM NaCl, 0.05% Tween 80, pH 6.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

N-6His

16 kDa

> 95 % as determined by reducing SDS-PAGE.

Pro25-Ser146

Interleukin-21;IL-21;IL21;Il21

Q9ES17