Elabscience

Recombinant Mouse CD16-2/FCGR4 Protein (His Tag)(Active)

Product Code:
 
PKSM040893
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Mouse
Regulatory Status:
 
RUO
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
 
The product is shipped at ambient temperature. Upon receipt store it immediately at the storage temperature listed.
Storage:
 
Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
 

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CodeSizePrice
PKSM040893-100ug100ug£664.00
Quantity:
PKSM040893-1mg1mg£4,795.00
Quantity:
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Further Information

Abbreviation:
CD16-2;FCGR4
Accession:
NP_653142.2
Activity:
Measured by its binding ability in a functional ELISA. Immobilized mouse FCGR4 at 10 ug/ml (100 ul/well) can bind recombinant human IgG1 (Fc). The EC50 of human IgG1 (Fc) is 0.11-0.25 ug/ml.
Background:
Fcgr4, also known as CD16-2, is one of the receptors for Fc region of IgG which involve in immune responses. Fcgr4 mainly functions in cellular response to lipopolysaccharide, NK T cell proliferation, regulation of sensory perception of pain, wound healing etc. Three groups are included for Fc γ receptors (FcR), and they are Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). Among these, CD64 possess high affinity even for monomeric IgG, while CD32 and CD16 display a relative lower affinity for IgG. Genes encodes these receptors are diverse differing by species and cell types. The aggregation of FcR having immunoreceptor tyrosine-based activation motifs (ITAMs) activates sequentially src family tyrosine kinases and syk family tyrosine kinases that connect transduced signals to common activation pathways shared with other receptors. FcR with ITAMs elicit cell activation, endocytosis, and phagocytosis. Fcgr4 belongs to Fc γ RIII (CD16) group.
Calculated MW:
22.4 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
ObservedMW:
25-35 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Gln 203
Target Synonym:
Low Affinity Immunoglobulin Gamma Fc Region Receptor IV;FcgR4;4833442P21Rik;CD16-2;FcgammaRIV;Fcgr3a;FcgRIV;Fcrl3

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