Elabscience

Recombinant Human GFRA1/GDNFRA Protein (Fc Tag)

Product Code:
 
PKSH032481
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
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CodeSizePrice
PKSH032481-10ug10ug£126.00
Quantity:
PKSH032481-50ug50ug£180.00
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Abbreviation:
GFRA1;GDNFRA
Accession:
P56159
Background:
Glial Cell Line-Derived Neurotrophic Factor Family Receptor α-1 (GDNFRα1) is a glycosylphosphatidylinositol (GPI) linked cell surface protein belonging to GDNF-family receptor α subtype which consists of at least four members. GFRα1and GFRα2 are the cognate co-receptor for the neurotrophic factor neurturin mediating the NRTN-induced autophosphorylation and activation of the RET tyrosine kinase receptor. Soluble GFRαs released enzymatically from the cell surface by phosphatidylinositol phospholipase C, as well as recombinantly produced soluble GFRα1, can also bind with high affinity to GDNF and trigger the activation of Ret tyrosine kinase. Human GFRα1 shares 93% amino acid identity with mouse GFRα1.The expression of the various GFRαs are differentially regulated in the central and peripheral nervous system, suggesting complementary roles for the GFRαs in mediating the activities of the GDNF family of neurotrophic factors.
Calculated MW:
72.3 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-Fc
ObservedMW:
85 kDa
Purity:
> 90 % as determined by reducing SDS-PAGE.
Sequence:
Asp25-Lys429
Target Synonym:
GDNF Family Receptor Alpha-1;GDNF Receptor Alpha-1;GDNFR-Alpha-1;GFR-Alpha-1;RET Ligand 1;TGF-Beta-Related Neurotrophic Factor Receptor 1;GFRA1;GDNFRA;RETL1;TRNR1
UNIProt ID:
P56159

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