Elabscience

Recombinant Human CD32a/FCGR2A Protein (H131, His Tag)(Active)

Product Code:
 
PKSH032418
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Application:
 
Bio-Layer Interferometry
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
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PKSH032418-10ug10ug£170.00
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PKSH032418-50ug50ug£315.00
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Further Information

Abbreviation:
CD32a;FCGR2A
Accession:
P12318
Activity:
Loaded Human CD32a-His on HIS1K Biosensor, can bind Anti-Human HER2 mAb with an affinity constant of 0.6 uM as determined in BLI assay.
Background:
Human FcγRs are divided into three classes designated FcγRI (CD64); FcγRII (CD32); and FcγRIII (CD16); which generate multiple isoforms; are recognized. The activating- type receptor either has or associates non-covalently with an accessory subunit that has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. FcγRI binds IgG with high affinity and functions during early immune responses; whereas FcγRII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses.Human CD32; also known as Low affinity immunoglobulin γ Fc region receptor II-a (IgG Fc receptor II-a); FcγRII A or FCGR2A Protein; is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM-bearing adapter subunit; FcRγ; CD32a (FcγRII A) delivers an activating signal upon ligand binding; and results in the initiation of inflammatory responses including cytolysis; phagocytosis; degranulation; and cytokine production. The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fcγ RII B; and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
Calculated MW:
21.1 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His
ObservedMW:
25-32 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Ala36-Ile218(H167)
Target Synonym:
Low affinity immunoglobulin gamma Fc region receptor II-a;IgG Fc receptor II-a;CDw32;Fc-gamma RII-a;Fc-gamma-RIIa;FcRII-a;CD32;FCGR2A;FCG2;FCGR2A1;IGFR2;CD32A;CDw32;Fc gamma RIIA;FCG2;FcGR;FCGR2
UNIProt ID:
P12318

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