Elabscience

Recombinant Human EGFR/ErbB1 Protein (aa 25-645, Fc Tag)(Active)

Product Code:
 
PKSH032398
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
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CodeSizePrice
PKSH032398-10ug10ug£170.00
Quantity:
PKSH032398-50ug50ug£315.00
Quantity:
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Abbreviation:
EGFR;ErbB1
Accession:
P00533
Activity:
Immobilized Human EGF(Cat: PKSH033687) at 10ug/ml(100 ul/well) can bind Human EGFR-Fc.
Background:
EGFR is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK; PI3 kinase-AKT; PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16; activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling.
Calculated MW:
95.7 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-Fc
ObservedMW:
130 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Leu25-Ser645
Target Synonym:
Epidermal growth factor receptor;EGFR;Proto-oncogene c-ErbB-1;Receptortyrosine-protein kinase erbB-1;EGFR
UNIProt ID:
P00533

Documents