Elabscience

MAP2K2 Polyclonal Antibody

Product Code:
 
E-AB-12553
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
-20°C
1 / 3
Western Blot analysis of Hela, NIH/3T3 and Jurkat cell using MAP2K2 Polyclonal Antibody at dilution of 1:1900
2 / 3
Immunohistochemistry of paraffin-embedded Human gastic cancer using MAP2K2 Polyclonal Antibody at dilution of 1:100
3 / 3
Immunohistochemistry of paraffin-embedded Human ovarian cancer using MAP2K2 Polyclonal Antibody at dilution of 1:100
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Western Blot analysis of Hela, NIH/3T3 and Jurkat cell using MAP2K2 Polyclonal Antibody at dilution of 1:1900
Immunohistochemistry of paraffin-embedded Human gastic cancer using MAP2K2 Polyclonal Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded Human ovarian cancer using MAP2K2 Polyclonal Antibody at dilution of 1:100

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E-AB-12553-20uL20uL£125.00
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E-AB-12553-60uL60uL£172.00
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E-AB-12553-120uL120uL£237.00
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E-AB-12553-200uL200uL£344.00
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Further Information

Abbreviation:
MAP2K2
Background:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
44kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-1:5000, IHC 1:100-1:300
Immunogen:
Synthetic peptide of human MAP2K2
Purification method:
Affinity purification
Target Synonym:
Cardiofaciocutaneous syndrome;CFC syndrome;CFC4;Dual specificity mitogen activated protein kinase kinase 2;Dual specificity mitogen-activated protein kinase kinase 2;ERK activator kinase 2;FLJ26075;MAP kinase kinase 2;map2k2;MAPK / ERK kinase 2;MAPK/ERK kinase 2;MAPKK 2;MAPKK2;MEK 2;MEK2;Microtubule associated protein kinase kinase 2;Mitogen activated protein kinase kinase 2;Mitogen activated protein kinase kinase 2 p45;MKK 2;MKK2;MP2K2;OTTHUMP00000165826;OTTHUMP00000165827;PRKMK 2;PRKMK2
UNIProt ID:
P36507

Documents