Elabscience

NLRP3 Polyclonal Antibody

Product Code:
 
E-AB-93354
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunofluorescence (IF)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze/thaw cycles.
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Western blot analysis of RAW264.7 using NLRP3 Polyclonal Antibody at 1:500 dilution.Raw264.7 cells were treated by LPS (1 ug/ml) at 37°C for 8 hours.
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Immunofluorescence analysis of HepG2 cells using NLRP3 Polyclonal Antibody at dilution of 1:50 (40x lens). Blue:DAPI for nuclear staining.
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Western blot analysis of RAW264.7 using NLRP3 Polyclonal Antibody at 1:500 dilution.Raw264.7 cells were treated by LPS (1 ug/ml) at 37°C for 8 hours.
Immunofluorescence analysis of HepG2 cells using NLRP3 Polyclonal Antibody at dilution of 1:50 (40x lens). Blue:DAPI for nuclear staining.

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E-AB-93354-60uL60uL£210.00
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E-AB-93354-120uL120uL£291.00
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E-AB-93354-200uL200uL£431.00
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Further Information

Abbreviation:
NLRP3
Background:
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NLRP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. The SARS-CoV 3a protein, a transmembrane pore-forming viroporin, has been shown to activate the NLRP3 inflammasome via the formation of ion channels in macrophages. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, neonatal-onset multisystem inflammatory disease (NOMID), keratoendotheliitis fugax hereditarian, and deafness, autosomal dominant 34, with or without inflammation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000,IF 1:50-1:200
Immunogen:
Recombinant fusion protein of mouse NLRP3
ObservedMW:
110KDa
Purification method:
Affinity purification
Target Synonym:
AII; AVP; FCU; MWS; FCAS; KEFH; CIAS1; FCAS1; NALP3; C1orf7; CLR1.1; DFNA34; PYPAF1; AGTAVPRL
UNIProt ID:
Q8R4B8

Documents