Elabscience

Recombinant Human ERN1/IRE1 Protein (aa 465-977, His & GST Tag)(Active)

Product Code:
 
PKSH030346
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt store it immediately at < -20°C.
Storage:
 
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
 

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PKSH030346-50ug50ug£652.00
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Further Information

Abbreviation:
ERN1;IRE1
Accession:
O75460-1
Activity:
1. Kinase activity untested 2. The specific activity was determined to be 5 nmol/min/mg using MBP as substrate
Background:
The encoded protein contains two functional catalytic domains; a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins; regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
Calculated MW:
86 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
Baculovirus-Insect Cells
Formulation:
Supplied as sterile solution of 20mM Tris, 500mM NaCl, 10% glycerol, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
N-His & GST
ObservedMW:
90 kDa
Purity:
> 80 % as determined by reducing SDS-PAGE.
Sequence:
Pro 465-Leu 977
Target Synonym:
hIRE1p;IRE1;IRE1a;IRE1P
UNIProt ID:
O75460

Documents