Elabscience

Recombinant Human Cathepsin Z Protein (His Tag)(Active)

Product Code:
 
PKSH031822
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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PKSH031822-50ug50ug£773.00
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This product comes from: China.
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Further Information

Abbreviation:
Cathepsin Z
Accession:
Q9UBR2
Activity:
Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK (Dnp)-OH, R&D Systems, Catalog # ES005. The specific activity is > 800 pmoles/min/ug.
Background:
Cathepsin Z (CTSZ); also known as Cathepsin X or CATX; belongs to the C1 family of lysosomal cysteine proteases. Its gene structure and activity properties show several unique features that distinguish it clearly from other human cysteine proteases. It has a very short pro-region that shows no similarity to those of other cathepsins and a three-residue insertion motif that forms a characteristic ‘mini loop’. Cathepsin Z exhibits mono- and di-peptidase activity at its C-terminus; and in contrast to cathepsin B; it does not act as an endopeptidase. It is restricted to the cells of theimmune system; predominantly monocytes; macrophages and dendritic cells. Cathepsin Z is widely expressed in human tissues; suggesting that this enzyme could be involved in the normal intracellular protein degradation taking place in all cell types. It is capable to cleave regulatory motifs at C-terminus affecting the function of targeted molecules. Cathepsin X may regulate also the maturation of dendritic cells; a process; which is crucial in the initiation of adaptive immunity. Furthermore; higher levels of Cathepsin Z are also found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa; especially after infection by Helicobacter pylori. Cathepsin Z is also ubiquitously distributed in cancer cell lines and in primary tumors from different sources; suggesting that this enzyme may participate in tumor progression.
Calculated MW:
33 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
Purity:
> 97 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Val 303
Target Synonym:
Cathepsin Z;Cathepsin P;Cathepsin X;CTSZ
UNIProt ID:
Q9UBR2

Documents